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ORIGINAL ARTICLE
Year : 2020  |  Volume : 2  |  Issue : 1  |  Page : 19-23

Prognostic value of endothelin-1 level in diabetic patients with coronary artery disease


1 Department of Cardiology, Shibin Elkom Teaching Hospital, General Organization of Teaching Hospitals and Institutes, Ministry of Health, Minoufia, Egypt
2 Department of Cardiology, Faculty of Medicine, Menoufia University, Shibin El-Kom, Minoufia, Egypt
3 Department of Biochemistry, Faculty of Medicine, Menoufia University, Shibin El-Kom, Minoufia, Egypt
4 Department of Cardiology, Police Academic Hospital, Ministry of Interior, Cairo, Egypt

Correspondence Address:
Dr. Mostafa Attia Eldegwi
Asem Street, Shibin El-Kom, Minoufia
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ACCJ.ACCJ_2_20

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Background and Objectives: ET-1 has been demonstrated to play a role in endothelial dysfunction and inflammation, both of which are actively involved in the pathophysiology of the onset and progression of CAD. Diabetes mellitus (DM) increases the risk of CAD and has unfavorable effects on the vascular endothelium, hence, the importance of assessing this plasma marker and its relation to the severity of CAD in diabetic patients. The aim of this work is to study the prognostic value of the plasma level of the new marker, endothelin-1 (ET-1), in diabetic patients with coronary artery disease (CAD). Methods: Seventy patients with coronary artery lesions of not < 50% in at least one main coronary artery were randomized into 35 diabetics (Group I) and 35 nondiabetics (Group II). Twenty patients with normal coronaries as a control group (Group III) were also enrolled. The severity of coronary artery lesions was assessed by GINSINI score (GS) and SYNTAX score, and then, the relationship between them and ET-1 level was evaluated. Results: The ET-1 levels were significantly higher in Group I with higher GS values of 34.29 ± 11.7 points and SYNTAX scores of 18.4 ± 11.17 points than in Group II with lower GS values of 23.23 ± 8.14 points and SYNTAX of scores 12.06 ± 12.11 points (ET-1 was 187.93 ± 146.61 ng/L in Group I vs. 76.30 ± 91.83 ng/L in Group II, P = 0.001). ET-1 levels were significantly higher in Group I than in Group III (187.93 ± 146.61 ng/L vs. 26.16 ± 7.32 ng/L, P = 0.001). ET-1 levels were significantly higher in Group II than in Group III (76.30 ± 91.83 ng/L vs. 26.16 ± 7.32 ng/L, P = 0.001). Conclusion: There is a positive correlation between DM and both ET-1 levels and the severity of coronary artery lesions, P = 0.001.


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