Comparison of demographics and outcomes of acute heart failure patients with reduced, mid-range, and preserved ejection fraction

Mohammed Al-Jarallah; Rajesh Rajan; Hussein Heshmat; Ibrahim Al-Zakwani; Raja Dashti; Bassam Bulbanat; Mustafa Ridha; Kadhim Sulaiman; Alawi A Alsheikh-Ali; Prashanth Panduranga; Khalid F AlHabib; Jassim Al Suwaidi; Wael Al-Mahmeed; Hussam AlFaleh; Abdelfatah Elasfar; Ahmed Al-Motarreb; Nooshin Bazargani; Nidal Asaad; Haitham Amin

doi:10.4103/2666-6979.298607

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ORIGINAL ARTICLE

Year : 2020 \| Volume : 2 \| Issue : 2 \| Page : 86-94

Comparison of demographics and outcomes of acute heart failure patients with reduced, mid-range, and preserved ejection fraction Mohammed Al-Jarallah¹, Rajesh Rajan¹, Hussein Heshmat², Ibrahim Al-Zakwani³, Raja Dashti¹, Bassam Bulbanat¹, Mustafa Ridha⁴, Kadhim Sulaiman⁵, Alawi A Alsheikh-Ali⁶, Prashanth Panduranga⁷, Khalid F AlHabib⁸, Jassim Al Suwaidi⁹, Wael Al-Mahmeed¹⁰, Hussam AlFaleh⁸, Abdelfatah Elasfar¹¹, Ahmed Al-Motarreb¹², Nooshin Bazargani¹³, Nidal Asaad¹⁴, Haitham Amin¹⁵ ¹ Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Kuwait City, Kuwait ² Department of Cardiology, Kasr Al Ainy Medical School, Cairo University, Cairo, Egypt ³ Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman ⁴ Division of Cardiology, Al-Dabous Cardiac Centre, Al Adan Hospital, Kuwait City, Kuwait ⁵ Department of Cardiology, Royal Hospital, and Director General of Specialized Medical Care, Ministry of Health, Muscat, Oman ⁶ Department of Cardiology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates ⁷ Department of Cardiology, Royal Hospital, Muscat, Oman ⁸ Department of Cardiac Sciences, King Fahad Cardiac Centre, King Saud University, Riyadh, Saudi Arabia ⁹ Department of Adult Cardiology, Hamad Medical Corporation and Qatar Cardiovascular Research Centre, Doha, Qatar ¹⁰ SCleveland Clinic, Heart and Vascular Institute, Abu Dhabi, United Arab Emirates ¹¹ Department of Adult Cardiology, King Salman Heart Centre, King Fahad Medical City, Riyadh, Saudi Arabia; Department of Cardiology, Tanta University, Tanta, Egypt ¹² Department of Internal Medicine, Faculty of Medicine, Sana'a University, Sana'a, Yemen ¹³ Department of Cardiology, Dubai Hospital, Dubai, United Arab Emirates ¹⁴ Department of Adult Cardiology, Hamad Medical Corporation, Doha, Qatar ¹⁵ Mohammed Bin Khalifa Cardiac Centre, Manama, Bahrain Correspondence Address: Dr. Rajesh Rajan Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Kuwait City 13001 Kuwait Source of Support: None, Conflict of Interest: None DOI: 10.4103/2666-6979.298607

Background: Heart failure (HF) burden in the developing world is not well quantified. Objectives: The objective is to evaluate the demographics and outcomes of acute HF patients with reduced ejection fraction (EF) (<40%) (HFr EF), HF with midrange EF (40%–49%) (HFmr EF) and HF with preserved EF (≥50%) (HFp EF) in the Arabian Gulf. Methods: Gulf CARE registry analyzed 4577 HF patients admitted to 47 hospitals in seven Middle Eastern countries (Kuwait, Oman, Qatar, Saudi Arabia, United Arab Emirates, Bahrain, and Yemen.) Analyses were performed using multivariate statistical techniques. Results: The overall median age was 60 (50–70) years and 63% (n = 2887) were male. The most prominent comorbidities included hypertension (61%; n = 2783), coronary artery disease (60%; n = 2762), and diabetes mellitus (49%; n = 2258). A total of 59% (n = 2683) of the patients had HFr EF, 21% (n = 962) had HFmr EF and 20% (n = 932) had HFp EF. Compared to those with HFr EF, patients with HFmr EF and HFp EF were more likely to be associated with hypertension (57% vs. 67% vs. 64%; P < 0.001), diabetes mellitus (47% vs. 57% vs. 51%; P = 0.002), and higher systolic blood pressure (133 vs. 143 vs. 143 mmHg; P < 0.001). Multiple logistic regressions demonstrated that there were no significant differences among the groups with regards to the 3-month (overall adjusted P value; P = 0.188) and 12-month (P = 0.220) cumulative all-cause mortality. The results also indicated that there were no significant differences among the groups with regards to the 3-month (P = 0.117) and 12-month (P = 0.244) re-hospitalization rates for HF. Conclusions: No significant differences among the groups with regards to 3-month and 12-month all-cause mortality and re-hospitalization rates for HF were observed between the groups in the Arabian Gulf.



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