Creative Commons Open Access Journal No author-side fee 
  • Users Online: 78
  • Print this page
  • Email this page
Submit article
Year : 2021  |  Volume : 3  |  Issue : 1  |  Page : 20-28

Identification of altered serum proteins in rheumatic heart diseases through mitral stenosis and the potential clinical implications

1 Department of Biochemistry, Molecular Cardiology Unit, Centre for Excellence in Genomic Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India
2 Dean Madurai Medical College & Govt Rajaji Hospital, Madurai, Tamil Nadu, India

Correspondence Address:
Govindan Sadasivam Selvam
Department of Biochemistry, Molecular Cardiology Unit, Center for Excellence in Genomic Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai - 625 021, Tamil Nadu
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ACCJ.ACCJ_42_20

Rights and Permissions

Background: Rheumatic heart disease (RHD) results from group A beta-hemolytic streptococcal pharyngeal infection is an autoimmune sequela of acute or recurrent episodes of acute rheumatic fever (ARF). This study is focused on identifying heart tissue-specific proteins implicated in the secondary immunopathogenesis of RHD. Methods: Sera from 49 RHD patients and 32 controls were probed in 2DE to study the differential expression of proteins. After 2DE, the spots were analyzed and identified using ESI-MS. A total of 1082 protein spots were detected in RHD patients and controls. Results: Two protein spots were significantly down-regulated (p≤0.01) and 34 protein spots were significantly up-regulated (p≤0.01) compared to controls. The differentially expressed protein spots were trypsin-digested and identified as hyaluronan-mediated motility receptor (RHAMM), troponin 1, janus kinase and microtubule interacting protein 1 (Jakmip 1), nuclear ubiquitous casein and cyclin-dependent kinase substrate 1, basal body-orientation factor 1 and muscle-related coiled-coil protein. A positive correlation was established with the up-regulated and down-regulated expression of these proteins suggests them as potential biomarker for RHD. Conclusion: This study highlights rheumatic mitral stenosis and regurgitation, an active inflammatory process and provides novel information about the proteins thereby elaborates the knowledge of physiology and etiology of this disease.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded129    
    Comments [Add]    

Recommend this journal