Clinical outcomes after transcatheter aortic valve replacement stratified by hemoglobin levels: A retrospective cohort pilot study

Retaj Al Haroun; Mohammed Al Jarallah; Rajesh Rajan; Raja Dashti; Nader Alasousi; Vladimir Kotevski; Ahmed Said Taha Mousa; Joud Al Balool; Gary Tse; Kobalava Davidovna Zhanna; Ahmad Al-Saber; Parul Setiya; Peter A Brady; Adham Hassan Ali Almowafy

doi:10.4103/ACCJ.ACCJ_19_22

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ORIGINAL ARTICLE

Year : 2022 \| Volume : 4 \| Issue : 2 \| Page : 66-70

Clinical outcomes after transcatheter aortic valve replacement stratified by hemoglobin levels: A retrospective cohort pilot study Retaj Al Haroun¹, Mohammed Al Jarallah², Rajesh Rajan³, Raja Dashti², Nader Alasousi², Vladimir Kotevski², Ahmed Said Taha Mousa², Joud Al Balool⁴, Gary Tse⁵, Kobalava Davidovna Zhanna⁶, Ahmad Al-Saber⁷, Parul Setiya⁸, Peter A Brady⁹, Adham Hassan Ali Almowafy² ¹ Department of Medicine, Faculty of Medicine, Royal College of Surgeons, Dublin, Ireland ² Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait ³ Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait; Department of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics Named after V.S. Moiseev, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia ⁴ Department of Medicine, Faculty of Medicine, Kuwait University, Jabriya, Kuwait ⁵ Cardiovascular Analytics Group, Hong Kong; Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China ⁶ Department of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics Named after V.S. Moiseev, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia ⁷ Department of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom ⁸ Department of Agrometeorology, College of Agriculture, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India ⁹ Department of Cardiology, Illinois Masonic Medical Center, Chicago, IL, USA Correspondence Address: Dr. Rajesh Rajan Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City - 15003 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ACCJ.ACCJ_19_22

Background: Anemia is a prevalent comorbidity in patients undergoing aortic valve replacement. Objectives: The objectives of this study were to define baseline parameters of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) to determine procedural risk and mortality outcomes stratified by hemoglobin (Hb) levels. Methods: Retrospective study of a population of patients with severe AS undergoing TAVR with the Edwards SAPIEN 3 valve between 2018 and 2021 at Sabah Al-Ahmad Cardiac Centre, Al Amiri Hospital, Kuwait. Two cohorts were identified based on Hb level: Hb <13 and Hb ≥13 g/dl. Results: A total of 61 patients were included. The mean age was 73.5 ± 9.0 years, with a higher prevalence of females. The cohort with lower Hb had lower body surface area (2.0 ± 0.1 vs. 1.8 ± 0.2, P = 0.035) and bioprosthesis size (26.5 ± 1.8 vs. 24.4 ± 1.8, P = 0.001). Based on echocardiography, patients with higher Hb levels had a higher prevalence of aortic regurgitation in addition to stenosis (P = 0.029). Conclusions: Baseline anemia is a common comorbidity in patients with severe AS undergoing TAVR. However, in terms of procedural outcomes and mortality, Hb levels were not a predictor of post-TAVR complications or in-hospital death.



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